In the last few years, a great interest has emerged in investigating the pleiotropic effects of Glucagon Like Peptide-1 Receptor Agonists (GLP-1RAs). While GLP-1RAs ability to lower plasma glucose and to induce weight loss has allowed them to be approved for the treatment of diabetes and obesity, consistent evidences from in vitro studies and preclinical models suggested that GLP-1RAs have anti-inflammatory properties and that may modulate the immune-system. Notably, such anti-inflammatory effects target different pathways in different tissues, underling the broad spectrum of GLP-1RAs actions. This review examines some of the currently proposed molecular mechanisms of GLP-1RAs actions and explores their potential benefits in reducing inflammatory responses, which may well suggest a future therapeutic use of GLP-1RAs in new indications.
第一作者单位：[1]ASST Fatebenefratelli Sacco, Div Endocrinol, Milan, Italy
通讯作者：
通讯机构：[1]ASST Fatebenefratelli Sacco, Div Endocrinol, Milan, Italy[2]Univ Milan, Dept Biomed & Clin Sci L Sacco, Pediat Clin Res Ctr Romeo & Enrica Invernizzi, Int Ctr T1D, Milan, Italy[8]Harvard Med Sch, Boston Childrens Hosp, Nephrol Div, Boston, MA 02115 USA[*1]Harvard Med Sch, Boston Childrens Hosp, Nephml Div, 300 Longwood Ave Enders Bldg 5th Floor En511, Boston, MA 02115 USA
推荐引用方式(GB/T 7714)：
Bendotti Giulia,Montefusco Laura,Lunati Maria Elena,et al.The anti-inflammatory and immunological properties of GLP-1 Receptor Agonists[J].PHARMACOLOGICAL RESEARCH.2022,182:doi:10.1016/j.phrs.2022.106320.
APA：
Bendotti, Giulia,Montefusco, Laura,Lunati, Maria Elena,Usuelli, Vera,Pastore, Ida...&Fiorina, Paolo.(2022).The anti-inflammatory and immunological properties of GLP-1 Receptor Agonists.PHARMACOLOGICAL RESEARCH,182,
MLA：
Bendotti, Giulia,et al."The anti-inflammatory and immunological properties of GLP-1 Receptor Agonists".PHARMACOLOGICAL RESEARCH 182.(2022)
医学