详情页 - 聚合机构库演示平台

当前位置：首页 > 详情页

Depression Status, Lifestyle, and Metabolic Factors With Subsequent Risk for Major Cardiovascular Events: The China Cardiometabolic Disease and Cancer Cohort (4C) Study.

文献详情

资源类型：

Pubmed体系：

作者：

单位： [1]Division of Endocrinology,Department of Internal Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China. [2]Branch of National Clinical Research Center for Metabolic Disease, Wuhan, China. [3]Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China. [4]The Affiliated Hospital of Luzhou Medical College, Luzhou, China. [5]The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. [6]Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. [7]The First Hospital of Jilin University, Changchun, China. [8]The First Affiliated Hospital of Guangxi Medical University, Nanning, China. [9]The First Hospital of Lanzhou University, Lanzhou, China. [10]Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, China. [11]Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China. [12]Affiliated Hospital of Guiyang Medical College, Guiyang, China. [13]Dalian Municipal Central Hospital, Dalian, China. [14]Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. [15]Chinese People's Liberation Army General Hospital, Beijing, China. [16]Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China. [17]Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [18]The Second Affiliated Hospital of Harbin Medical University, Harbin, China. [19]The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. [20]Qilu Hospital of Shandong University, Jinan, China. [21]Central Hospital of Shanghai Jiading District, Shanghai, China. [22]The First Affiliated Hospital of Anhui Medical University, Hefei, China. [23]The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. [24]Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China. [25]Karamay Municipal People's Hospital, Xinjiang, China. [26]The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. [27]Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [28]Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

出处：

DOI：

ISSN：

关键词： depression lifestyle risk factor metabolic risk factor major cardiovascular event prospective cohort study

摘要：

We aimed to evaluate the association between depression and major cardiovascular events and test whether the relationship between depression and cardiovascular events is influenced by lifestyle or metabolic risk factors.The China Cardiometabolic Disease and Cancer Cohort (4C) Study was a nationwide, multicenter, prospective cohort study. About 92,869 participants without cardiovascular disease or cancer at baseline were included. Depression status was evaluated by the Patient Health Questionnaire-9 (PHQ-9). Lifestyle information was collected by the questionnaire, and metabolic risk factors including waist circumference, blood pressure, lipid profiles, and plasma glucose were measured. Major cardiovascular events including cardiovascular death, myocardial infarction, stroke, and hospitalized or treated heart failure events were validated based on medical records.During an average of 3.8 years of follow-up, we detected 2,076 cardiovascular events and showed that participants with depressive symptoms had an increased risk for cardiovascular events after adjustments [hazard ratio (HR): 1.29; 95% confidence index (CI): 1.08-1.53]. Stratified on metabolic risk status, the relationship between depression and cardiovascular events tended to be stronger according to the increasing numbers of metabolic risk factors, with HR (95% CI) of 0.98 (0.72-1.35) in the category with 0-2 metabolic risk factors, 1.36 (0.996-1.87) and 1.47 (1.13-1.92) for those with 3, and 4-5 metabolic risk factors, respectively, indicating an interaction effect (P = 0.039).Depression was independently associated with an increased risk of major cardiovascular events. The effect was particularly prominent among populations at higher metabolic risk.Copyright © 2022 Chen, Liu, Yang, Chen, Wan, Qin, Yan, Wang, Qin, Luo, Tang, Huo, Hu, Ye, Shi, Gao, Su, Mu, Zhao, Chen, Zeng, Li, Shen, Chen, Zhang, Wang, Deng, Liu, Wu, Yang, Li, Xu, Xu, Wang, Zhao, Lu, Bi, Yu, Wang and Ning.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2021]版：

大类 | 3 区医学

小类 | 3 区心脏和心血管系统

最新[2025]版：

大类 | 3 区医学

小类 | 3 区心脏和心血管系统

第一作者：

第一作者单位： [1]Division of Endocrinology,Department of Internal Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China. [2]Branch of National Clinical Research Center for Metabolic Disease, Wuhan, China.

共同第一作者：

通讯作者：

通讯机构： [1]Division of Endocrinology,Department of Internal Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China. [2]Branch of National Clinical Research Center for Metabolic Disease, Wuhan, China. [27]Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [28]Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：

Depression Status, Lifestyle, and Metabolic Factors With Subsequent Risk for Major Cardiovascular Events: The China Cardiometabolic Disease and Cancer Cohort (4C) Study.

文献详情

相关文献