YAP1 (Yes-associated protein 1) is one of the principal factors that mediates oncogenesis by acting as a driver of gene expression. It has been confirmed to play an important role in organ volume control, stem cell function, tissue regeneration, tumorigenesis and tumor metastasis. Recent research findings show that YAP1 is correlated with the stemness of liver cancer stem cells, and liver cancer stem cells are closely associated with YAP1-induced tumor initiation and progression. This article reviews the advancements made in research on the mechanisms by which YAP1 promotes liver cancer stem cells and discusses some potential mechanisms that require further study.
基金：
National Natural Science Foundation of China [82073090, 82103597]
第一作者单位：[1]Huazhong Univ Sci & Technol,Tongji Hosp,Inst Hepatopancreatobililary Surg,Hepat Surg Ctr,Tongji Med Coll,Wuhan 430030,Peoples R China
通讯作者：
通讯机构：[1]Huazhong Univ Sci & Technol,Tongji Hosp,Inst Hepatopancreatobililary Surg,Hepat Surg Ctr,Tongji Med Coll,Wuhan 430030,Peoples R China[2]Shanxi Med Univ, Shanxi Bethune Hosp, Shanxi Acad Med Sci, Dept Hepatobiliary Surg, Taiyuan 030032, Peoples R China[3]Huazhong Univ Sci & Technol,Shanxi Tongji Hosp,Tongji Med Coll,Taiyuan 030032,Peoples R China
推荐引用方式(GB/T 7714)：
Wu Haofeng,Liu Yachong,Liao Zhibin,et al.The role of YAP1 in liver cancer stem cells: proven and potential mechanisms[J].BIOMARKER RESEARCH.2022,10(1):doi:10.1186/s40364-022-00387-z.
APA：
Wu, Haofeng,Liu, Yachong,Liao, Zhibin,Mo, Jie,Zhang, Qiaofeng...&Zhang, Lei.(2022).The role of YAP1 in liver cancer stem cells: proven and potential mechanisms.BIOMARKER RESEARCH,10,(1)
MLA：
Wu, Haofeng,et al."The role of YAP1 in liver cancer stem cells: proven and potential mechanisms".BIOMARKER RESEARCH 10..1(2022)
