Neurochemical alterations of different cerebral regions in rats with myocardial ischemia-reperfusion injury based on proton nuclear magnetic spectroscopy analysis.
单位：[1]Department of Gastrointestinal Surgery, Zhongnan Hospital, Wuhan University, Wuhan, China.[2]The Clinical Medical Research Center of Peritoneal Cancer of Wuhan, Clinical Cancer Study Center of Hubei Province, Key Laboratory of Tumor Biological Behavior of Hubei Province, Wuhan, China.[3]Departments of Anesthesiology and Pain Medicine,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China.华中科技大学同济医学院附属同济医院麻醉科[4]School of Human and Social Sciences, University of West London, London, UK.[5]Department of Anesthesiology, The First Affiliated Quanzhou Hospital of Fujian Medical University, Quanzhou, China.[6]Department of Orthopedics,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China.华中科技大学同济医学院附属同济医院外科学系骨科
Recent studies have demonstrated a complex and dynamic neural crosstalk between the heart and brain. A heart-brain interaction has been described regarding cardiac ischemia, but the cerebral metabolic mechanisms involved are unknown.Male Sprague Dawley rats were randomly allocated into 2 groups: those receiving myocardial ischemia-reperfusion surgery (IR group, n =10) and surgical controls (Con group, n=10). These patterns of metabolic abnormalities in different brain regions were assessed using proton magnetic resonance spectroscopy (PMRS).Results assessed by echocardiography showed resultant cardiac dysfunction following heart ischemia-reperfusion. Compared with the control group, the altered metabolites in the IR group were taurine and choline, and differences mainly occurred in the thalamus and brainstem.Alterations in cerebral taurine and choline are important findings offering new avenues to explore neuroprotective strategies for myocardial ischemia-reperfusion injury. These results provide preliminary evidence for understanding the cerebral metabolic process underlying myocardial ischemia-reperfusion injury in rats.
基金：
This work was supported by grants from the National Natural Science Foundation of P.R. China (No. 81670240 and 81873467 to H.B. X, 81770283 and 82070302 to M.H. F), the Clinical Medical Research Center of Peritoneal Cancer of Wuhan (No.2015060911020462), the Research Foundation of Health and Family Planning Commission of Hubei Province (No.WJ2015MA010, No.WJ2017M249), the Natural Science Foundation of Hubei Province (No.2015CFA027), the National Natural Science Foundation of Hubei Province (No. 2016CFB625 to H.B. X), and the Medical innovation project in Fujian Province (No. 2017-CX-48 to S.Y. L).
第一作者单位：[1]Department of Gastrointestinal Surgery, Zhongnan Hospital, Wuhan University, Wuhan, China.[2]The Clinical Medical Research Center of Peritoneal Cancer of Wuhan, Clinical Cancer Study Center of Hubei Province, Key Laboratory of Tumor Biological Behavior of Hubei Province, Wuhan, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Feng Mao-Hui,Li Zhi-Xiao,Wang Qian,et al.Neurochemical alterations of different cerebral regions in rats with myocardial ischemia-reperfusion injury based on proton nuclear magnetic spectroscopy analysis.[J].Aging.2021,13(2):2294-2309.doi:10.18632/aging.202250.
APA：
Feng Mao-Hui,Li Zhi-Xiao,Wang Qian,Manyande Anne,Li Yu-Juan...&Xiang Hong-Bing.(2021).Neurochemical alterations of different cerebral regions in rats with myocardial ischemia-reperfusion injury based on proton nuclear magnetic spectroscopy analysis..Aging,13,(2)
MLA：
Feng Mao-Hui,et al."Neurochemical alterations of different cerebral regions in rats with myocardial ischemia-reperfusion injury based on proton nuclear magnetic spectroscopy analysis.".Aging 13..2(2021):2294-2309
医学