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Strategies for Biomaterial-Based Spinal Cord Injury Repair via the TLR4-NF-κB Signaling Pathway.

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收录情况： ◇ SCIE ◇ EI

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单位： [1]Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, [2]Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, [3]Department of Orthopedics, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, China

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关键词： biomaterial spinal cord injury autophagy TLR4-NF-κB signaling pathway

摘要：

The repair and motor functional recovery after spinal cord injury (SCI) has remained a clinical challenge. Injury-induced gliosis and inflammation lead to a physical barrier and an extremely inhibitory microenvironment, which in turn hinders the recovery of SCI. TLR4-NF-κB is a classic implant-related innate immunomodulation signaling pathway and part of numerous biomaterial-based treatment strategies for SCI. Numerous experimental studies have demonstrated that the regulation of TLR4-NF-κB signaling pathway plays an important role in the alleviation of inflammatory responses, the modulation of autophagy, apoptosis and ferroptosis, and the enhancement of anti-oxidative effect post-SCI. An increasing number of novel biomaterials have been fabricated as scaffolds and carriers, loaded with phytochemicals and drugs, to inhibit the progression of SCI through regulation of TLR4-NF-κB. This review summarizes the empirical strategies for the recovery after SCI through individual or composite biomaterials that mediate the TLR4-NF-κB signaling pathway.Copyright © 2022 Lv, Shen, Cheng, Chen, Ding, Yuan, Zhao and Zhang.

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出版当年[2021]版：

大类 | 3 区工程技术

小类 | 2 区综合性期刊

最新[2025]版：

大类 | 3 区生物学

小类 | 3 区生物工程与应用微生物 4 区工程：生物医学

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出版当年[2020]版：

Q1 MULTIDISCIPLINARY SCIENCES

最新[2023]版：

Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q2 ENGINEERING, BIOMEDICAL

影响因子： 4.3 最新[2023版] 5.1 最新五年平均 5.89 出版当年[2020版] 5.973 出版当年五年平均 3.644 出版前一年[2019版] 6.064 出版后一年[2021版]

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第一作者单位： [1]Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China,

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