单位：[1]Institute of Organ Transplantation, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan,China华中科技大学同济医学院附属同济医院器官移植研究所器官移植[2]Key Laboratory of Organ, Wuhan, China[3]Transplantation, Ministry of Education, Wuhan, China[4]NHC Key Laboratory of OrganTransplantation, Wuhan, China[5]Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China[6]Departmentof Urology, the First Affiliated Hospital of Anhui Medical University, Hefei, China[7]Institute of Urology, Anhui Medical University, Hefei, China[8]Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, Hefei, China
To explore the role of phosphatidylinositol-3-kinase/protein kinase B and alpha serine/threonine protein kinase PI3K/PKB (also known as PI3K/Akt) signaling pathway in liver ischemia reperfusion injury.The PI3K/Akt signaling pathway is one of the major signal transduction pathways that regulates numerous cellular activities in vivo. The main functions of this pathway include induction of stem cell differentiation and metastasis, promotion of cell proliferation, inhibition of apoptosis, and regulation of tissue inflammation, tumor growth, and invasion. Liver ischemia reperfusion injury is an inevitable clinical problem that can occur during liver transplantation, liver resection, and various circulatory shock events, and it is one of the primary reasons for postoperative liver dysfunction, and poor disease outcome and patient prognosis. In recent years, it has been found that PI3K/Akt signaling pathway is closely related to liver ischemia reperfusion injury.In this review, a large number of relevant literatures were collected to explain the biological basis of PI3K/Akt signaling pathway and its role in liver ischemia reperfusion injury. The review was based on a PubMed search using the terms "liver ischemia reperfusion injury", "PI3K/Akt signaling pathway", and "PI3K/Akt signaling pathway AND liver ischemia reperfusion injury", so as to understand the complex interaction between them.Activated PI3K/Akt signaling pathway can exert anti-inflammatory, antioxidant stress, antiapoptosis and autophagy regulation effects through downstream related targeted pathways and proteins, thus alleviating liver ischemia-reperfusion injury. Therefore, the regulation of PI3K/Akt signaling pathway is expected to become an effective targeted pathway for clinical prevention and alleviation of liver ischemia reperfusion injury.
基金：
National Natural Science Foundation of China (grant No. 82170772, 81873623 and 81570678), the Major State Basic Research Development Program of China (grant No. 2013CB530803), the Clinical Research Physician Program of Tongji Medical College, HUST and the NonProfit Central Research Institute Fund of Chinese Academy of Medical Sciences (grant No. 2018PT32018).
第一作者单位：[1]Institute of Organ Transplantation, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan,China[2]Key Laboratory of Organ, Wuhan, China[3]Transplantation, Ministry of Education, Wuhan, China[4]NHC Key Laboratory of OrganTransplantation, Wuhan, China[5]Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China
通讯作者：
通讯机构：[1]Institute of Organ Transplantation, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan,China[2]Key Laboratory of Organ, Wuhan, China[3]Transplantation, Ministry of Education, Wuhan, China[4]NHC Key Laboratory of OrganTransplantation, Wuhan, China[5]Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China[*1]Institute of Organ Transplantation, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
推荐引用方式(GB/T 7714)：
wang mengqin,zhang ji,gong nianqiao.Role of the PI3K/Akt signaling pathway in liver ischemia reperfusion injury: a narrative review.[J].Annals Of Palliative Medicine.2022,11(2):806-817.doi:10.21037/apm-21-3286.
APA：
wang mengqin,zhang ji&gong nianqiao.(2022).Role of the PI3K/Akt signaling pathway in liver ischemia reperfusion injury: a narrative review..Annals Of Palliative Medicine,11,(2)
MLA：
wang mengqin,et al."Role of the PI3K/Akt signaling pathway in liver ischemia reperfusion injury: a narrative review.".Annals Of Palliative Medicine 11..2(2022):806-817
